Nitric oxide inhibits an interaction between JNK1 and c-Jun through nitrosylation.

@article{Park2006NitricOI,
  title={Nitric oxide inhibits an interaction between JNK1 and c-Jun through nitrosylation.},
  author={H S Park and J L Mo and Eui-Ju Choi},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={351 1},
  pages={281-6}
}
Nitric oxide (NO) has been shown to negatively regulate c-Jun N-terminal kinase (JNK) through S-nitrosylation. Here, we show that disruption of an interaction between JNK and its substrate c-Jun is an important mechanism underlying the NO-mediated inhibition of JNK signaling. Endogenous NO, which was generated by interferon-gamma treatment, suppressed anisomycin-stimulated JNK activity in microglial BV-2 cells. The interferon-gamma-induced suppression of JNK1 activation in BV-2 cells was… CONTINUE READING

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