Nitric oxide inhibition of coxsackievirus replication in vitro.


Nitric oxide is a radical molecule with antibacterial, -parasitic, and -viral properties. We investigated the mechanism of NO inhibition of Coxsackievirus B3 (CVB3) replication in vitro by determining the effect of NO upon a single replicative cycle of CVB3 grown in HeLa cells. Transfection of inducible NO synthase cDNA into HeLa cells reduces the number of… (More)


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@article{Zaragoz1997NitricOI, title={Nitric oxide inhibition of coxsackievirus replication in vitro.}, author={Crist{\'o}bal Zaragoz{\'a} and Catalina Ocampo and Marta Saura and A. McMillan and Carol Lowenstein}, journal={The Journal of clinical investigation}, year={1997}, volume={100 7}, pages={1760-7} }