Nitric oxide inhibition abolishes sleep-wake differences in cerebral circulation.

@article{Zoccoli2001NitricOI,
  title={Nitric oxide inhibition abolishes sleep-wake differences in cerebral circulation.},
  author={Giovanna Zoccoli and Daniel Allen Grant and Jennene Wild and Adrian Mark Walker},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 6},
  pages={H2598-606}
}
Nitric oxide (NO), being produced by active neurones and also being a cerebral vasodilator, may couple brain activity and blood flow in sleep, particularly during active sleep (AS), which is characterized by widespread neural activation and markedly elevated cerebral blood flow (CBF) compared with quiet wakefulness (QW) and quiet sleep (QS). This study examined CBF and cerebral vascular resistance (CVR) in lambs (n = 6) during spontaneous sleep-wake cycles before and after infusion of N(omega… CONTINUE READING