Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion.

@article{Liu2007NitricOI,
  title={Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion.},
  author={Xiaoshun Liu and Yanming Huang and Peter Pokreisz and Pieter Vermeersch and Glenn Marsboom and Marc Swinnen and Eric Verbeken and Jos{\'e} Agostinho Santos and Marijke Pellens and Hilde Gillijns and Frans Van de Werf and Kenneth D. Bloch and Stefan P. Janssens},
  journal={Journal of the American College of Cardiology},
  year={2007},
  volume={50 8},
  pages={808-17}
}
OBJECTIVES The purpose of this study was to test if nitric oxide (NO) could improve microvascular perfusion and decrease tissue injury in a porcine model of myocardial ischemia and reperfusion (I/R). BACKGROUND Inhaled NO is a selective pulmonary vasodilator with biologic effects in remote vascular beds. METHODS In 37 pigs, the midportion of the left anterior descending coronary artery was occluded for 50 min followed by 4 h of reperfusion. Pigs were treated with a saline infusion (control… CONTINUE READING