Nitric oxide induces the apoptosis of human BCR-ABL-positive myeloid leukemia cells: evidence for the chelation of intracellular iron

@article{FerryDumazet2002NitricOI,
  title={Nitric oxide induces the apoptosis of human BCR-ABL-positive myeloid leukemia cells: evidence for the chelation of intracellular iron},
  author={H. Ferry-Dumazet and M. Mamani-Matsuda and M. Dupouy and F. Belloc and D. Thiolat and G. Marit and M. Arock and J. Reiffers and M. Mossalayi},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={708-715}
}
Anti-leukemia activity of human macrophages involves the generation of nitric oxide (NO) derivatives. However, leukemic transformation may involve mechanisms that rescue cells from NO-mediated apoptosis. In the present work, we analyzed the effects of exogenous NO on the proliferation of BCR-ABL+ chronic myelogenous leukemia (CML) cells. As normal leukocytes, the proliferation of leukemia cells was inhibited by SNAP (S-nitroso-N-acetyl-penicillamine), GEA (Oxatriazolium amino-chloride), and SIN… Expand
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