Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures.

Abstract

The neutral ceramidase is a key enzyme in the regulation of cellular ceramide levels. Previously we have reported that stimulation of rat renal mesangial cells with nitric oxide (NO) donors leads to an inhibition of neutral ceramidase activity which is due to increased degradation of the enzyme. This and the concomitant activation of the sphingomyelinase… (More)

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@article{Franzen2002NitricOI, title={Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures.}, author={Rochus Franzen and Josef Martin Pfeilschifter and Andrea Huwiler}, journal={FEBS letters}, year={2002}, volume={532 3}, pages={441-4} }