Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C.

Abstract

Ceramide levels are strongly increased by stimulation of renal mesangial cells with nitric oxide (NO). This effect was shown previously to be due to a dual action of NO, comprising an activation of sphingomyelinases and an inhibition of ceramidase activity. In this study we show that the NO-triggered inhibition of neutral ceramidase activity is paralleled… (More)

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@article{Franzen2002NitricOI, title={Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C.}, author={Rochus Franzen and Doriano Fabbro and Armaz Aschrafi and Josef Martin Pfeilschifter and Andrea Huwiler}, journal={The Journal of biological chemistry}, year={2002}, volume={277 48}, pages={46184-90} }