Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes.

@article{Uchiyama2002NitricOI,
  title={Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes.},
  author={Takamichi Uchiyama and Hajime Otani and Takayuki Okada and Hideki Ninomiya and Masakuni Kido and Hiroji Imamura and Shunji Nogi and Yonosuke Kobayashi},
  journal={Journal of molecular and cellular cardiology},
  year={2002},
  volume={34 8},
  pages={1049-61}
}
Excessive nitric oxide (NO) production has been implicated in the pathophysiology of cardiomyocyte (CMC) apoptosis and necrosis induced by ischemia/reperfusion, inflammation and NO-donating chemicals. Although caspases are known to be involved in apoptosis, the present study examined whether caspases also play a role in NO-induced CMC necrosis. Neonatal rat CMCs were labeled with Annexin-V and propidium iodide, and apoptosis and necrosis were analyzed by confocal images and fluorescence… CONTINUE READING

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