Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.

@article{He2014NitricOI,
  title={Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.},
  author={Hao He and Yong-Sheng Feng and Ling-He Zang and Weiwei Liu and Li-qin Ding and Lixia Chen and Ning Kang and Toshihiko Hayashi and Shin-ichi Tashiro and Satoshi Onodera and Feng Qiu and Takashi Ikejima},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2014},
  volume={71},
  pages={128-35}
}
Physalin A is an active withanolide isolated from Physalis alkekengi var. franchetii, a traditional Chinese herbal medicine named Jindenglong, which has been used for the treatment of sore throat, hepatitis, eczema and tumors in China. Our previous study demonstrated that physalin A induced apoptosis and cyto-protective autophagy in A375-S2 human melanoma cells. Induction of reactive oxygen species (ROS) with physalin A triggered apoptosis. In this study, NO generated by physalin A induced… CONTINUE READING

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