Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway.

@article{Akool2005NitricOI,
  title={Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway.},
  author={el-Sayed Akool and Anke Doller and Roswitha M{\"u}ller and Paul Gutwein and Cuiyan Xin and Andrea Huwiler and Josef Martin Pfeilschifter and Wolfgang Eberhardt},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 47},
  pages={39403-16}
}
Excessive accumulation of the extracellular matrix is a hallmark of many inflammatory and fibrotic diseases, including those of the kidney. This study addresses the question whether NO, in addition to inhibiting the expression of MMP-9, a prominent metalloprotease expressed by mesangial cells, additionally modulates expression of its endogenous inhibitor TIMP-1. We demonstrate that exogenous NO has no modulatory effect on the extracellular TIMP-1 content but strongly amplifies the early… CONTINUE READING