Nitric oxide induces HIF-1α stabilization and expression of intestinal trefoil factor in the damaged rat jejunum and modulates ulcer healing

@article{Riao2011NitricOI,
  title={Nitric oxide induces HIF-1α stabilization and expression of intestinal trefoil factor in the damaged rat jejunum and modulates ulcer healing},
  author={Annia Ria{\~n}o and Dolores Ortiz-Masi{\'a} and Miriam Vel{\'a}zquez and Sara Calatayud and Juan V Esplugues and Mar{\'i}a D Barrachina},
  journal={Journal of Gastroenterology},
  year={2011},
  volume={46},
  pages={565-576}
}
The induction of intestinal trefoil factor (ITF) has been reported to depend on hypoxia-inducible factor-1 (HIF-1). Nitric oxide modulates HIF-1 activity. The present study aims to analyze the role of nitric oxide in jejunum damage induced by indomethacin and its ability to modulate epithelial function through the expression of ITF. Rats received indomethacin (7.5 mg/kg, s.c., twice), and a time course analysis of damage was performed (24–96 h after the first administration). In these animals… CONTINUE READING