Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40.

@article{Niedbala2007NitricOI,
  title={Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40.},
  author={Wanda Niedbala and Beilei Cai and Haiying Liu and Nick I. Pitman and Lynda Chang and Foo Yew Eddy Liew},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 39},
  pages={15478-83}
}
The principal aim of the immune system is to establish a balance between defense against pathogens and avoidance of autoimmune disease. This balance is achieved partly through regulatory T cells (Tregs). CD4(+)CD25(+) Tregs are either naturally occurring or induced by antigens and are characterized by the expression of the X-linked forkhead/winged helix transcription factor, Foxp3. Here we report a previously unrecognized subset of CD4(+)CD25(+) Tregs derived from CD4(+)CD25(-) T cells induced… CONTINUE READING

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