Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells.

@article{Zhang2005NitricOP,
  title={Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells.},
  author={Jianliang Zhang and B. Jin and Liuzhe Li and E. Block and J. Patel},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={288 4},
  pages={
          C840-9
        }
}
Persistent inhibition of cytochrome-c oxidase, a terminal enzyme of the mitochondrial electron transport chain, by excessive nitric oxide (NO) derived from inflammation, polluted air, and tobacco smoke contributes to enhanced oxidant production and programmed cell death or apoptosis of lung cells. We sought to determine whether the long-term exposure of pulmonary artery endothelial cells (PAEC) to pathophysiological concentrations of NO causes persistent inhibition of complex IV through redox… Expand
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  • 2011
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4
5
...

References

SHOWING 1-10 OF 74 REFERENCES
Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies.
Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.
Nitric Oxide and Mitochondrial Complex IV
Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase.
  • G. Brown
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2001
Oxidative stress and S‐nitrosylation of proteins in cells
Thioredoxin restores nitric oxide-induced inhibition of protein kinase C activity in lung endothelial cells
Nitric Oxide and Peroxynitrite Interactions with Mitochondria
Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase
...
1
2
3
4
5
...