Nitric oxide-induced conversion of cellular chelatable iron into macromolecule-bound paramagnetic dinitrosyliron complexes.

@article{Toledo2008NitricOC,
  title={Nitric oxide-induced conversion of cellular chelatable iron into macromolecule-bound paramagnetic dinitrosyliron complexes.},
  author={Jos{\'e} Carlos de Toledo and Charles A Bosworth and Seth W. Hennon and Harry A Mahtani and Hector A Bergonia and Jack R. Lancaster},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 43},
  pages={28926-33}
}
One of the most important biological reactions of nitric oxide (nitrogen monoxide, *NO) is its reaction with transition metals, of which iron is the major target. This is confirmed by the ubiquitous formation of EPR-detectable g=2.04 signals in cells, tissues, and animals upon exposure to both exogenous and endogenous *NO. The source of the iron for these dinitrosyliron complexes (DNIC), and its relationship to cellular iron homeostasis, is not clear. Evidence has shown that the chelatable iron… CONTINUE READING

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