Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function.

@article{Kakizawa2012NitricOC,
  title={Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function.},
  author={Sho Kakizawa and Toshiko Yamazawa and Yili Chen and Akihiro Ito and Takashi Murayama and Hideto Oyamada and Nagomi Kurebayashi and Osamu Sato and Masahiko Watanabe and Nozomu Mori and Katsuji Oguchi and Takashi Sakurai and Hiroshi Takeshima and Nobuhito Saito and Masamitsu Iino},
  journal={The EMBO journal},
  year={2012},
  volume={31 2},
  pages={417-28}
}
Mobilization of intracellular Ca(2+) stores regulates a multitude of cellular functions, but the role of intracellular Ca(2+) release via the ryanodine receptor (RyR) in the brain remains incompletely understood. We found that nitric oxide (NO) directly activates RyRs, which induce Ca(2+) release from intracellular stores of central neurons, and thereby promote prolonged Ca(2+) signalling in the brain. Reversible S-nitrosylation of type 1 RyR (RyR1) triggers this Ca(2+) release. NO-induced Ca(2… CONTINUE READING
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