Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function.

  title={Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function.},
  author={Sho Kakizawa and Toshiko Yamazawa and Yili Chen and Akihiro Ito and Takashi Murayama and Hideto Oyamada and Nagomi Kurebayashi and Osamu Sato and Masahiko Watanabe and Nozomu Mori and Katsuji Oguchi and Takashi Sakurai and Hiroshi Takeshima and Nobuhito Saito and Masamitsu Iino},
  journal={The EMBO journal},
  volume={31 2},
Mobilization of intracellular Ca(2+) stores regulates a multitude of cellular functions, but the role of intracellular Ca(2+) release via the ryanodine receptor (RyR) in the brain remains incompletely understood. We found that nitric oxide (NO) directly activates RyRs, which induce Ca(2+) release from intracellular stores of central neurons, and thereby promote prolonged Ca(2+) signalling in the brain. Reversible S-nitrosylation of type 1 RyR (RyR1) triggers this Ca(2+) release. NO-induced Ca(2… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 24 extracted citations


Publications referenced by this paper.
Showing 1-10 of 70 references

structure and functional expression from cDNA of the cardiac ryanodine receptor/calcium release

  • S Namiki, S Kakizawa, K Hirose, M Iino
  • J Physiol
  • 2005
Highly Influential
4 Excerpts

inhibitor, protects against focal cerebral ischemic damage

  • V Lev-Ram, LR Makings, PF Keitz, JP Kao, RY Tsien
  • 1995
Highly Influential
16 Excerpts

reduced expression of endoplasmic reticulum stress markers

  • T Malinski, F Bailey, ZG Zhang, M Chopp
  • Brain Res
  • 1993
Highly Influential
12 Excerpts

populations of the mammalian CNS together with NADPH diaphorase

  • DS Bredt, SH Snyder
  • 1994
Highly Influential
13 Excerpts

Similar Papers

Loading similar papers…