Nitric oxide in the kidney: synthesis, localization, and function.

  title={Nitric oxide in the kidney: synthesis, localization, and function.},
  author={Silke Bachmann and Peter H. Mundel},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  volume={24 1},
The characterization and cloning of constitutive and inducible nitric oxide (NO)-synthesizing enzymes and the development of specific inhibitors of the L-arginine NO pathway have provided powerful tools to define the role of NO in renal physiology and pathophysiology. There is increasing evidence that endothelium-derived NO is tonically synthesized within the kidney and that NO plays a crucial role in the regulation of renal hemodynamics and excretory function. Bradykinin and acetylcholine… CONTINUE READING


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