Nitric oxide in skeletal muscle

@article{Kobzik1994NitricOI,
  title={Nitric oxide in skeletal muscle},
  author={Lester Kobzik and Michael B. Reid and David S. Bredt and Jonathan S. Stamler},
  journal={Nature},
  year={1994},
  volume={372},
  pages={546-548}
}
REACTIVE oxygen intermediates modulate skeletal muscle contraction1,2, but little is known about the role of nitric oxide (NO). Here we show that rat skeletal muscle expresses neuronal-type NO synthase and that activity varies among several respiratory and limb muscles. Immunohistochemistry showed prominent staining of type II (fast) fibre cell membranes with antibodies against neuronal-type NO synthase. NO synthase activity in muscles correlated with type II fibre density. Resting diaphragm… Expand
Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance.
  • M. Reid
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  • Acta physiologica Scandinavica
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TLDR
Research published over the past few years makes it clear that skeletal muscle produces NO and that endogenous NO modulates muscle function, and much remains to be learned about the physiological importance of NO actions and about their underlying mechanisms. Expand
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  • Chemistry, Medicine
  • Medicine and science in sports and exercise
  • 2001
TLDR
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TLDR
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TLDR
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  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
A fundamental role for the concerted action of NO and O2 in physiological regulation of skeletal muscle contractility is revealed, and novel molecular aspects of myopathic disease are suggested. Expand
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TLDR
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