Nitric oxide in sepsis and endotoxaemia.

  title={Nitric oxide in sepsis and endotoxaemia.},
  author={James Roy Parratt},
  journal={The Journal of antimicrobial chemotherapy},
  volume={41 Suppl A},
Nitric oxide (NO) is one of many vasoactive substances released, from a variety of cells, under conditions of endotoxaemia and sepsis. Under physiological conditions it is produced by two constitutive calcium-dependent enzymes (nitric oxide synthase; NOS) in neurones (nNOS) and endothelial cells (eNOS) and has functions ranging from neurotransmission and vasodilatation to inhibition of platelet adhesion and aggregation. Following bacterial infection, especially with Gram-negative organisms, its… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 48 references

Regulation of vascular tone.

Canadian journal of physiology and pharmacology • 1995
View 4 Excerpts
Highly Influenced

Effect of bacterial lipopolysaccharide on function of rat small femoral arteries.

The American journal of physiology • 1994
View 4 Excerpts
Highly Influenced

L-arginine pathway in the sepsis syndrome.

Critical care medicine • 1993
View 4 Excerpts
Highly Influenced

Comparison of the effects of aminoguanidine and N -nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat

Wu, C.-C, H. Ruetten, C. Thiemermann
European Journal of Pharmacology • 1996

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