Nitric oxide in sepsis and endotoxaemia.

@article{Parratt1998NitricOI,
  title={Nitric oxide in sepsis and endotoxaemia.},
  author={James Roy Parratt},
  journal={The Journal of antimicrobial chemotherapy},
  year={1998},
  volume={41 Suppl A},
  pages={31-9}
}
Nitric oxide (NO) is one of many vasoactive substances released, from a variety of cells, under conditions of endotoxaemia and sepsis. Under physiological conditions it is produced by two constitutive calcium-dependent enzymes (nitric oxide synthase; NOS) in neurones (nNOS) and endothelial cells (eNOS) and has functions ranging from neurotransmission and vasodilatation to inhibition of platelet adhesion and aggregation. Following bacterial infection, especially with Gram-negative organisms, its… CONTINUE READING

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