Nitric oxide in pulp cell growth, differentiation, and mineralization.

  title={Nitric oxide in pulp cell growth, differentiation, and mineralization.},
  author={Rika Yasuhara and Tetsuo Suzawa and Yasuhiro Miyamoto and Xiao-Jing Wang and Mariko Takami and Aya Yamada and Ryutarou Kamijo},
  journal={Journal of dental research},
  volume={86 2},
Dental preparation sometimes causes transient congestion, edema, and necrosis of the pulp. We hypothesized that nitric oxide (NO) is involved in the pathophysiological changes in pulp after preparation. The mRNA and protein expression of the inducible isoform of NO synthase (iNOS) was examined in murine pulp after dental preparation. The effects of NO on the proliferation, mineralization, and apoptosis of pulp cells were also studied in vitro. We found that not only iNOS, but also mRNAs for… CONTINUE READING