Nitric oxide in preeclampsia: lack of evidence for decreased production.

  title={Nitric oxide in preeclampsia: lack of evidence for decreased production.},
  author={Romolo di Iorio and Emanuela Marinoni and Serena Emiliani and Barbara Villaccio and Ermelando Vinicio Cosmi},
  journal={European journal of obstetrics, gynecology, and reproductive biology},
  volume={76 1},
The purpose of our study was to determine the involvement of the L-arginine-NO system in preeclampsia. We studied 26 patients with preeclampsia and 27 normotensive pregnancies. Maternal and cord plasma, urine and amniotic fluid were assayed for nitric oxide metabolites (nitrite and nitrate) using the Griess reaction. Sections of placenta and fetal membranes were immunostained with polyclonal anti-endothelial and anti-neuronal nitric oxide synthase antibodies. The concentration of nitrate in the… CONTINUE READING

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