Nitric oxide formation from hydroxylamine by myoglobin and hydrogen peroxide.

@article{Taira1997NitricOF,
  title={Nitric oxide formation from hydroxylamine by myoglobin and hydrogen peroxide.},
  author={James Taira and Vladim{\'i}r Mi{\vs}{\'i}k and Peter Riesz},
  journal={Biochimica et biophysica acta},
  year={1997},
  volume={1336 3},
  pages={502-8}
}
Hydroxylamine (HA), which is a natural product of mammalian cells, has been shown to possess vasodilatory properties in several model systems. In this study, HA and methyl-substituted hydroxylamines, N-methylhydroxylamine (NMHA) and N,N-dimethylhydroxylamine (NDMHA), have been tested for their ability to generate free diffusible nitric oxide (NO) in the presence of myoglobin (Mb) and hydrogen peroxide. A NO-specific conversion of 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide… CONTINUE READING