Nitric oxide formation does not underlie the memory deficits produced by ibotenate injections into the nucleus basalis of rats.

@article{Harrington1994NitricOF,
  title={Nitric oxide formation does not underlie the memory deficits produced by ibotenate injections into the nucleus basalis of rats.},
  author={Charles A. Harrington and Stacey L Mobley and Gary L. Wenk},
  journal={Behavioral neuroscience},
  year={1994},
  volume={108 2},
  pages={277-83}
}
Basal forebrain (BF) injections of ibotenic (IBO) acid impair memory, whereas quisqualic (QUIS) acid injections do not. The authors investigated whether the cytotoxicity and differential behavioral effects of IBO and QUIS in rats depend on the generation of nitric oxide (NO). Injections of IBO or sodium nitroprusside (NP), but not QUIS, significantly increased BF NO formation, as determined by guanosine 3,5-cyclic monophosphate levels. IBO, alone or coinjected with methylene blue (MB), and QUIS… CONTINUE READING