Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells.

@article{Kanno2004NitricOF,
  title={Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells.},
  author={Shinichi Kanno and Peter K. M. Kim and Karim I. Sallam and Jing Lei and Timothy R Billiar and Larry L. Shears},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 33},
  pages={
          12277-81
        }
}
Stem cell therapy holds great promise for the replacement of damaged or dysfunctional myocardium. Nitric oxide (NO) has been shown to promote embryonic stem (ES) cell differentiation in other systems. We hypothesized that NO, through NO synthase gene transfer or exogenous NO exposure, would promote the differentiation of mouse ES cells into cardiomyocytes (CM). In our study, NO treatment increased both the number and the size of beating foci in embryoid body (EB) outgrowths. Within 2 weeks, 69… CONTINUE READING

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