Nitric oxide evoked p53-accumulation and apoptosis.

  title={Nitric oxide evoked p53-accumulation and apoptosis.},
  author={Bernhard Br{\"u}ne and Nicole Schneiderhan},
  journal={Toxicology letters},
  volume={139 2-3},
The tumor suppressor p53 accumulates under conditions of cellular stress and affects cell cycle progression and/or apoptosis. This has been exemplified for endogenously produced or exogenously supplied nitric oxide (NO) and thus accounts at least in part for cell destructive signaling qualities of this bioactive molecule and/or derived reactive nitrogen species. However, detailed mechanisms of toxicity and pathways of cell demise remain to be elucidated. Establishing that NO-treatment left the… CONTINUE READING
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