Nitric oxide enhances slow inactivation of voltage-dependent sodium currents in rat nodose neurons

@article{Bielefeldt1999NitricOE,
  title={Nitric oxide enhances slow inactivation of voltage-dependent sodium currents in rat nodose neurons},
  author={Klaus Bielefeldt and Carol A. Whiteis and Mark W Chapleau and Francois M Abboud},
  journal={Neuroscience Letters},
  year={1999},
  volume={271},
  pages={159-162}
}
Nitric oxide (NO) can alter neuronal excitability by decreasing the current through voltage-sensitive sodium channels. We hypothesized that NO inhibits sodium currents in part by promoting slow inactivation. We performed whole-cell voltage clamp experiments on sensory neurons from the nodose ganglion. The voltage-dependence of inactivation was determined after stepping the neurons to various potentials between -100 and 30 mV for 200 ms (fast inactivation) and 3 min (slow inactivation) prior to… CONTINUE READING

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Nitric oxide as an endogenous peripheral modulator of visceral sensory neuronal function.

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  • 2009
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