Nitric oxide enhances hydrogen peroxide-mediated endothelial permeability in vitro.

@article{Okayama1997NitricOE,
  title={Nitric oxide enhances hydrogen peroxide-mediated endothelial permeability in vitro.},
  author={Naotsuka Okayama and Christopher G. Kevil and Loisann Correia and David Jourd'heuil and Makoto Itoh and Matthew B Grisham and Jonathan Steven Alexander},
  journal={The American journal of physiology},
  year={1997},
  volume={273 5 Pt 1},
  pages={
          C1581-7
        }
}
The objective of this study was to evaluate the effects of nitric oxide (NO) on H2O2-mediated endothelial permeability. H2O2 (0.1 mM) increased permeability at 90 min to 298% of baseline. Spermine NONOate (SNO), an NO donor, at 0.1 or 1 mM did not alter permeability. However, 0.1 mM H2O2 + 1 mM SNO increased permeability to 764%, twice that of 0.1 mM H2O2 alone. These treatments were not directly toxic to endothelial cells. This NO effect was concentration dependent, inasmuch as 0.1 mM SNO did… CONTINUE READING

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