Nitric oxide enhances cyclooxygenase activity in articular cartilage

  title={Nitric oxide enhances cyclooxygenase activity in articular cartilage},
  author={Laura Manfield and D. Jang and George A. C. Murrell},
  journal={Inflammation Research},
Nitric oxide (NO) is a small messenger molecule synthesized by a family of enzymes, the nitric oxide synthases. Cyclooxygenases are a group of proinflammatory enzymes that release prostaglandins including prostaglandin E2 (PGE2). Both nitric oxide synthase and cyclooxygenase are involved in the inflammatory cascade of arthritis. However, the relationship between these two enzymes and their products has not been explored in articular cartilage. Here we show that in cultured bovine chondrocytes… CONTINUE READING