Nitric oxide-enhanced resistance to oral candidiasis.

@article{Elahi2001NitricOR,
  title={Nitric oxide-enhanced resistance to oral candidiasis.},
  author={Shokrollah Elahi and Gerald Pang and Robert B. Ashman and Robert D. Clancy},
  journal={Immunology},
  year={2001},
  volume={104 4},
  pages={
          447-54
        }
}
A murine model of oral candidiasis was used to show that nitric oxide (NO) is involved in host resistance to infection with Candida albicans in infection-'resistant' BALB/c and infection-'prone' DBA/2 mice. Following infection, increased NO production was detected in saliva. Postinfection samples of saliva inhibited the growth of yeast in vitro. Treatment with NG-monomethyl-L-arginine (MMLA), an inhibitor of NO synthesis, led to reduced NO production, which correlated with an increase in C… CONTINUE READING
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