Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis.

@article{Castillo2007NitricOC,
  title={Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis.},
  author={S. Sianna Castillo and Michal Levy and Chunbo Wang and Jyoti V. Thaikoottathil and Elaine Khan and Tzipora Goldkorn},
  journal={Experimental cell research},
  year={2007},
  volume={313 4},
  pages={816-23}
}
Reactive nitrogen species (RNS) are implicated in the pathophysiology of inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease. The molecular mechanisms and signaling events involved in lung cell injury by RNS are still poorly understood. In the current study, we observe a novel anti-apoptotic response to nitric oxide (NO) exposure (via the NO donors 3-morpholine-syndnonimine (SIN1) or papa-NONOate) of human airway epithelial (HAE) cells. NO exposure via the NO… CONTINUE READING

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