Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes.

@article{Henrotin1998NitricOD,
  title={Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes.},
  author={Yves Henrotin and Shu Xian Zheng and Gabriele Deby and Alain Labasse and J. M. Crielaard and JY. Reginster},
  journal={The Journal of rheumatology},
  year={1998},
  volume={25 8},
  pages={
          1595-601
        }
}
OBJECTIVE To investigate the effects of endogenously produced nitric oxide (NO) on interleukin 6 (IL-6), IL-8, prostaglandin E2 (PGE2), and proteoglycan production by human chondrocytes. METHODS Human articular chondrocytes were isolated from their extracellular matrix by triple successive enzymatic digestion of the cartilage and cultured 48 h in a well defined culture medium. IL-6 and IL-8 were directly assayed into culture media by specific enzyme amplified sensitivity immunoassays… CONTINUE READING

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