Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview.

@article{Ignarro2002NitricOD,
  title={Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview.},
  author={Louis Joseph Ignarro and Claudio Napoli and Joseph Loscalzo},
  journal={Circulation research},
  year={2002},
  volume={90 1},
  pages={21-8}
}
Nitric oxide (NO) mediates multiple physiological and pathophysiological processes in the cardiovascular system. Pharmacological compounds that release NO have been useful tools for evaluating the pivotal role of NO in cardiovascular physiology and therapeutics. These agents constitute two broad classes of compounds, those that release NO or one of its redox congeners spontaneously and those that require enzymatic metabolism to generate NO. In addition, several commonly used cardiovascular… CONTINUE READING