Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model.

@article{Ouyang2006NitricOA,
  title={Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model.},
  author={Nengtai Ouyang and Jennie L. Williams and George J. Tsioulias and Jianjun Gao and Michael J. Iatropoulos and Levy Kopelovich and Khosrow Kashfi and Basil Rigas},
  journal={Cancer research},
  year={2006},
  volume={66 8},
  pages={
          4503-11
        }
}
To evaluate the chemopreventive effect of nitric oxide-donating aspirin (NO-ASA), an ASA bearing a NO-releasing moiety, against pancreatic cancer, we studied six groups of female Syrian golden hamsters: groups 1 to 3 (n = 12 each) were given saline and groups 4 to 6 (n = 17) the carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) s.c. in five weekly injections (the first, 70 mg/kg, and the remaining, 20 mg/kg each). Control and BOP-treated hamsters were fed a NO-ASA 3,000 ppm or conventional ASA 3… CONTINUE READING

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K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas NO-ASA Prevents Pancreatic Cancer in Hamsters www.aacrjournals.org

M Tsutsumi, S Kondoh, O Noguchi
  • Cancer Res
  • 2006
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