Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation.

@article{Hundley2006NitricOA,
  title={Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation.},
  author={Thomas R. Hundley and Basil Rigas},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={316 1},
  pages={
          25-34
        }
}
Nitric oxide-donating aspirin (NO-aspirin), representing a new concept in the development of more efficacious nonsteroidal anti-inflammatory drugs, consists of traditional aspirin bearing -ONO(2), which releases NO. Conventional aspirin prevents human colon cancer, but its toxicity precludes its application as a chemopreventive agent. NO-aspirin seems safer and in cultured cancer cells it is >1000-fold more potent than aspirin. To determine the mechanism by which NO-aspirin inhibits cell growth… CONTINUE READING

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