Nitric oxide diffusion to red blood cells limits extracellular, but not intraphagosomal, peroxynitrite formation by macrophages.

@article{Prolo2015NitricOD,
  title={Nitric oxide diffusion to red blood cells limits extracellular, but not intraphagosomal, peroxynitrite formation by macrophages.},
  author={Carolina Prolo and Mar{\'i}a Noel {\'A}lvarez and N. P{\'e}rez R{\'i}os and Gonzalo Peluffo and Rafael Radi and Natalia Romero},
  journal={Free radical biology & medicine},
  year={2015},
  volume={87},
  pages={
          346-55
        }
}
Macrophage-derived nitric oxide ((•)NO) participates in cytotoxic mechanisms against diverse microorganisms and tumor cells. These effects can be mediated by (•)NO itself or (•)NO-derived species such as peroxynitrite formed by its diffusion-controlled reaction with NADPH oxidase-derived superoxide radical anion (O(2)(•-)). In vivo, the facile extracellular diffusion of (•)NO as well as different competing consumption routes limit its bioavailability for the reaction with O(2)(•-) and, hence… CONTINUE READING
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