Nitric oxide-dependent relaxation induced by M1 muscarinic receptor activation in the rat small intestine.

@article{Olgart1999NitricOR,
  title={Nitric oxide-dependent relaxation induced by M1 muscarinic receptor activation in the rat small intestine.},
  author={C. Olgart and Hanne Iversen},
  journal={British journal of pharmacology},
  year={1999},
  volume={127 1},
  pages={309-13}
}
The aim of the present study was to investigate whether muscarinic M1 receptor activation induces intestinal relaxation via nerve-dependent nitric oxide formation. Mechanical activity in longitudinal segments of rat jejunum was recorded isotonically in organ baths. The muscarinic M1 receptor agonist 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N,-trimethyl-2-butyn- 1-ammonium chloride (McN-A-343, 10(-7)-10(-4) M) induced a concentration-dependent relaxation of rat jejunum. Relaxations induced… CONTINUE READING

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