Nitric oxide decreases activity and levels of the 11S proteasome activator PA28 in the vasculature.

Abstract

The 11S proteasome activator (PA28) binds to the 20S proteasome and increases its ability to degrade small peptides. Expression of PA28 subunits (α, β, γ) is induced by interferon-γ stimulation. Inflammation plays a role in the development of neointimal hyperplasia, and we have previously shown that nitric oxide (NO) reduces neointimal hyperplasia in animal… (More)
DOI: 10.1016/j.niox.2012.04.006

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