Nitric oxide decreases [Ca2+]i in vascular smooth muscle by inhibition of the calcium current.

@article{Blatter1994NitricOD,
  title={Nitric oxide decreases [Ca2+]i in vascular smooth muscle by inhibition of the calcium current.},
  author={Lothar A Blatter and Withrow Gil Wier},
  journal={Cell calcium},
  year={1994},
  volume={15 2},
  pages={122-31}
}
Endothelium derived relaxing factor (nitric oxide, or NO) activates cytoplasmic guanylate cyclase in vascular smooth muscle and decreases vascular tone through cGMP-dependent mechanisms that are not yet understood fully. In cultured vascular smooth muscle cells (A7r5 cell line) sodium nitroprusside (NP), a vasodilator that decomposes into nitric oxide, lowered [Ca2+]i in cells in which [Ca2+]i was elevated after depolarization. NP decreased current through voltage-gated calcium channels, but… CONTINUE READING