Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles.

@article{Grange2001NitricOC,
  title={Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles.},
  author={Robert W. Grange and Eiji Isotani and Kim S. Lau and Kristine E. Kamm and Paul Lee Huang and James T Stull},
  journal={Physiological genomics},
  year={2001},
  volume={5 1},
  pages={
          35-44
        }
}
During skeletal muscle contraction, NO derived from neuronal nitric oxide synthase (nNOS) in skeletal muscle fibers or from endothelial cells (eNOS) may relax vascular smooth muscle contributing to functional hyperemia. To examine the relative importance of these pathways, smooth muscle myosin regulatory light chain (smRLC) phosphorylation was assessed as an index of vascular tone in isolated extensor digitorum longus (EDL) muscles from C57, nNOS(-/-), and eNOS(-/-) mice. The smRLC… CONTINUE READING

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