Nitric oxide contributes to substance P-induced increases in lung rapidly adapting receptor activity in guinea-pigs.

@article{Joad1997NitricOC,
  title={Nitric oxide contributes to substance P-induced increases in lung rapidly adapting receptor activity in guinea-pigs.},
  author={Jesse P. Joad and Kayleen S Kott and Ann C. Bonham},
  journal={The Journal of physiology},
  year={1997},
  volume={503 ( Pt 3)},
  pages={635-43}
}
1. Substance P induces fluid flux via nitric oxide, and fluid flux stimulates lung rapidly adapting receptors (RARs). We therefore proposed that nitric oxide contributes to substance P-evoked increases in RAR activity. Since substance P decreases dynamic compliance (Cdyn), which can stimulate RARs, we also determined whether nitric oxide contributed to substance P-induced effects on pulmonary function. 2. In anaesthetized guinea-pigs, the effects of substance P on RAR activity, Cdyn, pulmonary… CONTINUE READING

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