Nitric oxide contributes to multiorgan oxidative stress in acute experimental pancreatitis.

@article{Dabrowski1994NitricOC,
  title={Nitric oxide contributes to multiorgan oxidative stress in acute experimental pancreatitis.},
  author={Andrzej Dabrowski and Antoni Gabryelewicz},
  journal={Scandinavian journal of gastroenterology},
  year={1994},
  volume={29 10},
  pages={943-8}
}
BACKGROUND Nitric oxide is a highly reactive free radical gas. The study was undertaken to determine the nitric oxide contribution to oxidative stress in acute experimental pancreatitis induced in Wistar rats. METHODS Acute haemorrhagic pancreatitis was induced in male Wistar rats by means of a retrograde intraductal injection of 5% Na-taurocholate. The rats were treated with the nitric oxide donor, sodium nitroprusside (SNP) (0.25 mg/kg), or with N omega-nitro-L-arginine methyl ester (L-NAME… CONTINUE READING