Nitric oxide contributes to control of effusion in experimental otitis media.

@article{Ryan2001NitricOC,
  title={Nitric oxide contributes to control of effusion in experimental otitis media.},
  author={Allen F Ryan and Thecla Bennett},
  journal={The Laryngoscope},
  year={2001},
  volume={111 2},
  pages={301-5}
}
OBJECTIVES/HYPOTHESIS Nitric oxide (NO) is a small, short-lived free radical involved in cellular signaling and known to play a role in inflammation. It is generated on demand by the enzyme nitric oxide synthase (NOS) on arginine. We have previously found that mRNA encoding NOS is produced in the middle ear during otitis media. The role of NO was therefore explored in an experimental model of immune-mediated otitis media. STUDY DESIGN AND METHODS Guinea pigs were systemically immunized and… CONTINUE READING

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