Nitric oxide contributes to adriamycin's antitumor effect.

@article{Lind1997NitricOC,
  title={Nitric oxide contributes to adriamycin's antitumor effect.},
  author={D. Scott Lind and Maria I Kontaridis and Pamela D Edwards and Michael D. Josephs and Lyle L. Moldawer and Edward M. Copeland},
  journal={The Journal of surgical research},
  year={1997},
  volume={69 2},
  pages={
          283-7
        }
}
UNLABELLED Recently, several antitumor drugs have been shown to stimulate nitric oxide (NO) production. PURPOSE To determine if adriamycin induces NO production in breast cancer cells in vitro and whether NO contributes to adriamycin's antitumor effect in vivo. METHODS Murine breast cancer cells (EMT-6) were incubated with adriamycin (ADRIA, 0, 10, 100, 1000 microM) in the presence or absence of the NO synthase inhibitor aminoguanidine (AG, 1 mM). Twenty-four hours later nitrite… CONTINUE READING
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