Nitric oxide causes a cGMP-independent intracellular calcium rise in porcine endothelial cells-a paradox?

@article{Berkels2000NitricOC,
  title={Nitric oxide causes a cGMP-independent intracellular calcium rise in porcine endothelial cells-a paradox?},
  author={Reinhard Berkels and S Suerhoff and Renate Roesen and W Stockelhuber Klaus},
  journal={Microvascular research},
  year={2000},
  volume={59 1},
  pages={
          38-44
        }
}
This study was undertaken to investigate the influence of exogenous NO on intracellular calcium levels of porcine aortic endothelial cell culture monolayers. Spontaneous NO liberating substances with different half-life periods (NOC-9 [10 micromol/L] approximately 1 min, SNAP [10 micromol/L] approximately 4 h), and an aqueous NO gas solution [130 nmol/L] were added onto the monolayers. All three solutions induced a rapid and similar calcium rise in the endothelial cells. NOC-9 as a rapidly NO… CONTINUE READING
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