Nitric oxide augments fetal pulmonary artery endothelial cell angiogenesis in vitro.

@article{Balasubramaniam2006NitricOA,
  title={Nitric oxide augments fetal pulmonary artery endothelial cell angiogenesis in vitro.},
  author={Vivek Balasubramaniam and Anne M Maxey and Brian W. Fouty and Steven H. Abman},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={290 6},
  pages={
          L1111-6
        }
}
Growth and development of the lung normally occur in the low oxygen environment of the fetus. The role of this low oxygen environment on fetal lung endothelial cell growth and function is unknown. We hypothesized that low oxygen tension during fetal life enhances pulmonary artery endothelial cell (PAEC) growth and function and that nitric oxide (NO) production modulates fetal PAEC responses to low oxygen tension. To test this hypothesis, we compared the effects of fetal (3%) and room air (RA… 
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No signaling is improved and pulmonary vascular resistance is reduced in CH piglets treated with the l‐arginine‐NO precursor, l‐citrulline, and the changes would be accompanied by alterations in vascular endothelial growth factor (VEGF) signaling.
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How hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development are discussed.
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