Nitric oxide attenuates neutrophil-mediated myocardial contractile dysfunction after ischemia and reperfusion.

@article{Pabla1996NitricOA,
  title={Nitric oxide attenuates neutrophil-mediated myocardial contractile dysfunction after ischemia and reperfusion.},
  author={R. Pabla and A. Buda and D. Flynn and S. Blesse and A. M. Shin and M. J. Curtis and D. Lefer},
  journal={Circulation research},
  year={1996},
  volume={78 1},
  pages={
          65-72
        }
}
With the knowledge of NO as an antiadhesion molecule, we performed studies to investigate the effects of NO on postischemic polymorphonuclear leukocyte (PMN)-medicated myocardial contractile dysfunction. Studies were performed with isolated perfused rat hearts subjected to 20 minutes of global ischemia and 45 minutes of reperfusion. Human PMNs (50 million) were infused over the first 5 minutes of reperfusion, and the recovery of left ventricular function was compared with baseline values… Expand
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