Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter

  title={Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter},
  author={Hidde Bult and Guy E. E. Boeckxstaens and Paul A. Pelckmans and F. H. Jordaens and Yvan M. van Maercke and Arnold G. Herman},
INHIBITORY non-adrenergic non-cholinergic (NANC) nerves are thought to be important in the autonomie innervation of the gastrointestinal tract and other organ systems. The nature of their neurotransmitter is still debated. Speculation that nitric oxide (NO), formed from L-arginine in neuronal structures1 and other cells2, could act as a neurotransmitter, is not yet supported by demonstration of its release upon nerve stimulation. Using a superfusion bioassay, we report the release of a… CONTINUE READING

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