Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia.

@article{Ogawa1995NitricOA,
  title={Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia.},
  author={Hayato Ogawa and Aki Mizusawa and Yoshihiro Kikuchi and Wataru Hida and Hitoshi Miki and Kunio Shirato},
  journal={The Journal of physiology},
  year={1995},
  volume={486 ( Pt 2)},
  pages={495-504}
}
1. We examined the role of nitric oxide (NO) in respiratory regulation in the nucleus tractus solitarii (NTS), where L-glutamate release associated with peripheral chemoreceptor activation modulates the hypoxic ventilatory response. 2. Experiments were performed in unanaesthetized freely moving rats. First, the effects on the hypoxic ventilatory response of sodium nitroprusside (SNP, a NO donor) or NG-monomethyl-L-arginine (L-NMMA, a NO synthase inhibitor), microinjected into the NTS, were… CONTINUE READING