Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission.

  title={Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission.},
  author={Kenton M. Sanders and Sean M Ward},
  journal={The American journal of physiology},
  volume={262 3 Pt 1},
Part of the regulation of gastrointestinal (GI) smooth muscles is provided by nonadrenergic noncholinergic (NANC) nerves. Stimulation of these nerves, either by field stimulation or via neural reflex pathways, elicits hyperpolarization of postjunctional smooth muscle membranes referred to as inhibitory junction potentials and relaxation. The transmitter(s) that mediate NANC inhibitory neural transmission have been a controversial topic for nearly 30 years. Recent evidence suggests that nitric… CONTINUE READING
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