Nitric oxide as a bifunctional regulator of apoptosis.

  title={Nitric oxide as a bifunctional regulator of apoptosis.},
  author={Youngleem Kim and C A Bombeck and Timothy R Billiar},
  journal={Circulation research},
  volume={84 3},
I t was inevitable that important relationships between two of the most intensely studied topics in biomedical research, apoptosis and nitric oxide (NO), would become apparent. Apoptosis is essential to normal development as well as physiological cell turnover. Although apoptosis in excess can manifest as tissue damage, a failure to undergo apoptosis constitutes pathological cellular overgrowth. It is now evident that NO and its reaction products can either promote or prevent apoptosis in a… CONTINUE READING
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