Nitric oxide and vascular insulin resistance

@article{Wu2009NitricOA,
  title={Nitric oxide and vascular insulin resistance},
  author={Guoyao Wu and Cynthia J. Meininger},
  journal={BioFactors},
  year={2009},
  volume={35}
}
Obesity and type‐II diabetes are growing major health issues worldwide. They are the leading risk factors for vascular insulin resistance, which plays an important role in the pathogenesis of cardiovascular disease, the leading cause of death in developed nations. Recent studies have shown that reduced synthesis of nitric oxide (NO; a major vasodilator) from L‐arginine in endothelial cells is a major factor contributing to the impaired action of insulin in the vasculature of obese and diabetic… Expand
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Modulation of NO‐mediated pathways through dietary supplementation with L‐arginine or its precursor L‐citrulline may provide an effective, practical strategy to prevent and treat metabolic syndrome, including obesity, diabetes, and dyslipidemia in mammals, including humans. Expand
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Both pharmacological approaches and potential regenerative therapies hold promise for restoration of impaired endothelial cells in diabetic nephropathy. Expand
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A Mitochondrial Approach to Cardiovascular Risk and Disease.
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Regular physical activity has been shown to improve mitochondrial parameters and myocardial tolerance to ischemia-reperfusion (IR) and several approaches that act by improving mitochondrial function in the heart, contributing to decrease some of the risk factors associated to CVDs. Expand
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